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5 Best Enzymatic Drain Cleaners of 2026

Last Updated - 2026/04/03

1
Best Choice
21% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Zep
21% Off

Zep Drain Defense Enzymatic Drain Cleaner Powder 18 Ounces (Case of 2) ZDC16 - Safe for Pipes and Septic Systems

Zep

CA$76.50

CA$97.00
(21% Off)

More Details
Main highlights
- SAFE FOR: PVC and most other septic systems
- Helps prevent clogs in sinks, toilets and showers
- ENZYME BASED FORMULA: Breaks down drain-clogging elements. Use monthly to prevent future clogs from happening
- Certified, biodegradable formula, breaks down into carbon dioxide, minerals and water
- BREAKS DOWN: Into CO2, minerals and water
CA$76.50
CA$97.00 (21% Off)
2
Best Value

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Bio-Clean

Bio-clean Drain Septic Bacteria (2 lb.) (Packaging may vary)

Bio-Clean

CA$69.95

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Main highlights
- Up to 100 Drain Treatments.
- Special combination of natural bacteria and enzymes that DIGESTS dead organic waste found in your plumbing system.
- Multi Purpose. Kitchen sinks, showers, bath tubs, garbage disposals, septic tanks & fields, cat litter pans, RV's, boats and much more!
- Environmentally friendly and safe.
- Eliminates costly backups.
CA$69.95
3

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Green Gobbler

Green Gobbler Fresh Scent Drain Cleaner & Deodorizer Sticks- Prevents Sink & Shower Drain Clogs, Prevents Odors, Septic-Safe - 8 Count (2 PACK)

Green Gobbler

CA$15.99

More Details
Main highlights
- UTILIZES POWERFUL YET SLOW DISSOLVING enzymes to take care of lodged organic materials. Food and grease will stick to your drain like Velcro. Pretty gross. Luckily you can clear the gunk in your drain with a Bio-Flow Deodorizing Strip.
- ULTRA CONCENTRATED strips for powerful cleaning and deodorizing of household drain lines. Smelly drain? Bio-Flow Drain Strips will eat away at organic matter better than the no-name drain cleaner you have under your sink. Drop one strip into your drain and the slow-dissolving bacteria and enzymes will start to work instantly.
- SAFE ON ALL PIPES and septic systems (including old pipes and PVC pipes)
- PERFECT AS PART of a monthly drain cleaning routine. Traditional Use: Once a month, drop one Bio-Flow strip into the drain for cleaning and deodorizing. Perfect for kitchen and bathroom drains
- ELIMINATES & DIGESTS grease, oil, fats, scum and food quickly for easy drain cleaning. The gunk that’s stuck inside of your drain won’t stand a chance against Bio-Flow’s enzymes. Grease, oil, fats, scum, food: all gone in a matter of minutes. How’s that for easy drain maintenance?
CA$15.99
4

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Green Gobbler

Green Gobbler Main Line Drain Opener & Toilet Clog Remover, Odorless Formula, Septic Safe Hair Clog Remover, 128 Oz

Green Gobbler

CA$38.99

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Main highlights
CA$38.99
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Green Gobbler

Green Gobbler Main Line Drain Opener & Toilet Clog Remover, Odorless Formula, Septic Safe Hair Clog Remover, 128 Oz

Green Gobbler

CA$38.99

More Details
Main highlights
CA$38.99

5 Best Enzymatic Drain Cleaners of 2026

Zep Drain Defense Enzymatic Drain Cleaner Powder 18 Ounces (Case of 2) ZDC16 - Safe for Pipes and Septic Systems

Bio-clean Drain Septic Bacteria (2 lb.) (Packaging may vary)

Green Gobbler Fresh Scent Drain Cleaner & Deodorizer Sticks- Prevents Sink & Shower Drain Clogs, Prevents Odors, Septic-Safe - 8 Count (2 PACK)

Green Gobbler Main Line Drain Opener & Toilet Clog Remover, Odorless Formula, Septic Safe Hair Clog Remover, 128 Oz

Green Gobbler Main Line Drain Opener & Toilet Clog Remover, Odorless Formula, Septic Safe Hair Clog Remover, 128 Oz

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Drano Max Gel Drain Clog Remover and Cleaner, Unclogs and Removes Hair, Soap Scum, Blockages and More from Showers and Sinks, 3.8L

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