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5 Best Best Berberine Supplements of 2025

Last Updated - 2025/06/18

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Preferred Nutrition

Preferred Nutrition Berberine MAXIMUM POTENCY 1000 mg per Serving (2 caps, 500 mg each) for Cardiovascular Health & Supporting Blood Sugar Metabolism. 180 vcap, 90 Day Supply

Picked by 513 people in the last week

Preferred Nutrition

CA$59.99

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Main highlights
- VEGAN, NON-GMO & GLUTEN FREE
- SUPPORTS GLUCOSE METABOLISM: Manage healthy blood sugar levels with Berberis vulgaris (barberry), an alkaloid that occurs naturally in a variety of medicinal plants. Berberine inhibits some of the enzymes responsible for breaking down carbohydrates and starchy foods in the digestive tract. This helps lower the amount of glucose that is absorbed into the bloodstream.
- MAINTAINS CARDIOVASCULAR HEALTH, HEALTHY CHOLESTEROL & BLOOD LIPID LEVELS: Berberine helps the body manage blood lipid levels by stimulating AMPK activity (a protein enzyme) and supporting effective lipid metabolism by the liver.
- ISURA VERIFIED CLEAN: The INSURA seal is your assurance that this product is independently verified as clean and safe, and has been tested for up to 800 possible contaminants. This product is ISURA verified clean, one of the highest testing standards in the world.
CA$59.99
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Natural Factors

Natural Factors - WellBetX Berberine 500 mg, 120 capsules

Natural Factors

CA$39.97

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Main highlights
- Supports weight management
- Promotes insulin sensitivity
- Helps manage blood lipid levels
- Helps maintain healthy blood sugar balance
- Helps block the digestion of carbohydrates
CA$39.97
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Nutrali

New Berberine MAXIMUM POTENCY 1000mg per Serving (2 capsules 500mg each) Supports Blood Sugar Levels, Healthy Lipid (Fat) and Glucose Metabolism. Non-GMO, Vegan, Gluten Free, 90 Easy to Swallow Capsules- 1 pack

Nutrali

CA$32.99

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Main highlights
- SUPPORT WHOLE-BODY HEALTH - Each serving provides 1000mg of Berberine (500mg per capsule), a potent dose to optimize its health benefits. Harness the power of nature for comprehensive metabolic support.
- POWER PACKED PLANT EXTRACT – All-natural berberine is derived from plants and may help with Mental Clarity and improved Mood. Digestive Issues Resolved, Berberine has been found to help promote a healthy balance of gut bacteria. A Healthy gut is a Healthier you.
- NON-GMO, VEGAN, GLUTEN-FREE - We prioritize your well-being by ensuring our Berberine supplement is free from genetically modified organisms (GMOs), suitable for vegans, and gluten-free. Embrace a healthy lifestyle without compromise.
- CHOLESTEROL AND GLUCOSE METABOLISM - Lipids are the main fuel for energy metabolism in the heart. The increase of circulating lipids affects the uptake and utilization of fatty acids and glucose and also affects mitochondrial function.
CA$32.99
4
Best Value

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Organika

Organika Berberine - High Potency, Cholesterol and Glucose Metabolism Support, Helps Maintain Cardiovascular Health - 60vcaps

Organika

CA$27.89

CA$29.99
(7% Off)

More Details
Main highlights
- SUPPORT CANADIAN: A BC based, family owned and operated company for over 34 years. Proudly Canadian-made and manufactured in a GMP-certified facility and meticulously tested for purity and potency, delivering trusted quality and safety
- HIGH POTENCY: 500mg is the maximum dose of Berberine allowed per capsule. A maximum dose for every capsule for great value!
- GLUCOSE METABOLISM SUPPORT: Helps process and metabolise glucose to support health glucose levels
- CHOLESTEROL SUPPORT: Helps support the metabolism of cholesterol and lipids
- CARDIOVASCULAR SUPPORT: Helps supports aspects of cardiovascular health
CA$27.89
CA$29.99 (7% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Smoky Mountain Naturals, LLC

Berberine HCL Supplement | 1000mg | High Potency | Support Glucose Metabolism & Cardiovascular Health | 500mg Per Capsule | With Bitter Melon | Non-GMO, Third-Party Tested | 90 Ct. (45-Day Supply)

Smoky Mountain Naturals, LLC

CA$29.95

More Details
Main highlights
- WITH BITTER MELON EXTRACT: Our Berberine supplements provide 100mg of Bitter Melon Fruit extract per serving for additional glucose metabolism support.*
- WHOLE BODY BENEFITS: Berberine is a powerful antioxidant with full-body benefits. It has been used in Ayurveda for thousands of years to support overall wellness.*
- OUR DIFFERENCE: Berberine Complex by SMNutrition is Non-GMO, Third-Party Tested, and manufactured in a facility that adheres to cGMP guidelines.
- HIGH-POTENCY BERBERINE: Berberine HCL is the most recommended variation of Berberine available. Our formula provides a powerful 1000 mg per serving for ultimate support.
- GLUCOSE SUPPORT: Berberine has the unique ability to support an enzyme in our cells known as AMPK or “Active PK” which supports glucose metabolism.*
CA$29.95

5 Best Best Berberine Supplements of 2025

Preferred Nutrition Berberine MAXIMUM POTENCY 1000 mg per Serving (2 caps, 500 mg each) for Cardiovascular Health & Supporting Blood Sugar Metabolism. 180 vcap, 90 Day Supply

Natural Factors - WellBetX Berberine 500 mg, 120 capsules

New Berberine MAXIMUM POTENCY 1000mg per Serving (2 capsules 500mg each) Supports Blood Sugar Levels, Healthy Lipid (Fat) and Glucose Metabolism. Non-GMO, Vegan, Gluten Free, 90 Easy to Swallow Capsules- 1 pack

Organika Berberine - High Potency, Cholesterol and Glucose Metabolism Support, Helps Maintain Cardiovascular Health - 60vcaps

Berberine HCL Supplement | 1000mg | High Potency | Support Glucose Metabolism & Cardiovascular Health | 500mg Per Capsule | With Bitter Melon | Non-GMO, Third-Party Tested | 90 Ct. (45-Day Supply)

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Preferred Nutrition Berberine MAXIMUM POTENCY 1000mg per Serving (2 capsules, 500mg each) for Cardiovascular Health & Supporting Blood Sugar Metabolism. 120 vcap, 60 day supply.

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Berberine 1000mg | High Potency Complex | Supports Glucose Metabolism & Cardiovascular Health | Berberine Supplement with Bitter Melon | Made in Canada, Third Party Tested | 45 Day Supply | 90 Ct

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