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5 Best 5 Hydroxytryptophans of 2026

Last Updated - 2026/04/03

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

THORNE

Thorne 5-Hydroxytryptophan - Serotonin Production Support Supplement - 90 Capsules - 90 Servings

THORNE

CA$48.75

More Details
Main highlights
- Stress: Nutritional support for stress*
- Sleep: Supports restful sleep*
- NPN 80060101
- Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts). This product also contains no soy, dairy, yeast, shellfish, or fish
- Cravings: Helps decrease sugar cravings*
CA$48.75
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

THORNE

Thorne 5-Hydroxytryptophan - Serotonin Production Support Supplement - 90 Capsules - 90 Servings

THORNE

CA$48.75

More Details
Main highlights
- Stress: Nutritional support for stress*
- Sleep: Supports restful sleep*
- NPN 80060101
- Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts). This product also contains no soy, dairy, yeast, shellfish, or fish
- Cravings: Helps decrease sugar cravings*
CA$48.75
3

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Nature's Bounty

NATURE'S BOUNTY 5-HTP 100 mg Plus, Helps Promote Healthy Mood Balance, 51.8 g

Nature's Bounty

CA$26.24

More Details
Main highlights
- Promotes Healthy Mood Balance: NATURE'S BOUNTY 5-HTP 100 mg Plus helps to promote a healthy mood balance
- Non-medicinal Ingredients: Dibasic calcium phosphate, gelatin (bovine and/or porcine), magnesium stearate, silicon dioxide
- NATURE'S BOUNTY: Your best self starts here
- Medicinal Ingredients: L-5 hydroxytryptophan, valerian, magnesium, niacinamide, vitamin B6
- Directions & Dosage: Adults, take one (1) capsule three times per day with food; Use for a minimum of one week to see beneficial effects; Consult a healthcare practicioner for use beyond one year
- Contains: 120 5-HTP Plus 100 mg capsules
CA$26.24
4

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Nature's Bounty

NATURE'S BOUNTY 5-HTP 100 mg Plus, Helps Promote Healthy Mood Balance, 51.8 g

Nature's Bounty

CA$24.93

CA$26.24
(5% Off)

More Details
Main highlights
- Promotes Healthy Mood Balance: NATURE'S BOUNTY 5-HTP 100 mg Plus helps to promote a healthy mood balance
- Non-medicinal Ingredients: Dibasic calcium phosphate, gelatin (bovine and/or porcine), magnesium stearate, silicon dioxide
- NATURE'S BOUNTY: Your best self starts here
- Medicinal Ingredients: L-5 hydroxytryptophan, valerian, magnesium, niacinamide, vitamin B6
- Directions & Dosage: Adults, take one (1) capsule three times per day with food; Use for a minimum of one week to see beneficial effects; Consult a healthcare practicioner for use beyond one year
- Contains: 120 5-HTP Plus 100 mg capsules
CA$24.93
CA$26.24 (5% Off)
5
Best Value
17% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

NOW
17% Off

NOW Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support, 120 Veg Capsules

NOW

CA$28.11

CA$33.89
(17% Off)

More Details
Main highlights
- VEGAN CAPSULES/NEUROTRANSMITTER SUPPORT*: 5-HTP is the intermediate metabolite between the amino acid L-tryptophan and serotonin
- TYPICALLY USED AS A SLEEP SUPPLEMENT*/SUPPORTS POSITIVE MOOD AND RELAXATION*: 5-HTP supports the production of serotonin in the brain and central nervous system; serotonin can impact sleep, mood, appetite, and body temperature*
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
- FAMILY OWNED & OPERATED: Proudly made in Canada by a family owned and operated company.
- CERTIFICATIONS/CLASSIFICATIONS: Dairy Free, Egg Free, Kosher, Made without Gluten, Non-GMO, Nut Free, Soy Free, Vegan/Vegetarian
CA$28.11
CA$33.89 (17% Off)

5 Best 5 Hydroxytryptophans of 2026

Thorne 5-Hydroxytryptophan - Serotonin Production Support Supplement - 90 Capsules - 90 Servings

Thorne 5-Hydroxytryptophan - Serotonin Production Support Supplement - 90 Capsules - 90 Servings

NATURE'S BOUNTY 5-HTP 100 mg Plus, Helps Promote Healthy Mood Balance, 51.8 g

NATURE'S BOUNTY 5-HTP 100 mg Plus, Helps Promote Healthy Mood Balance, 51.8 g

NOW Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support, 120 Veg Capsules

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